Hazard Evaluation of Candidate Face Net Impregnant ENT-20127, Pentyl Mandelate

A hazard evaluation of the candidate face net impregnant technical grade pentyl mandelate (ENT 201127) was performed by means of laboratory animal studies using rats, rabbits, and guinea pigs. The technical grade compound did not produce primary irritation when applied to the intact or abraded skin...

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Bibliographic Details
Main Authors: Weeks,Maurice H, Pope,Conrad R, Macko,Joseph A. , Jr
Format: Report
Language:English
Subjects:
Bioassay
Exposure(Physiology)
Eye
Ingestion(Physiology)
Inhalation
Insect repellents
Irritant compounds
Laboratory animals
Lethal dosage
Mandelic acid/pentyl
Skin(Anatomy)
Toxicology
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Summary:A hazard evaluation of the candidate face net impregnant technical grade pentyl mandelate (ENT 201127) was performed by means of laboratory animal studies using rats, rabbits, and guinea pigs. The technical grade compound did not produce primary irritation when applied to the intact or abraded skin of rabbits. No corneal injury, iritis or conjunctivitis was observed after a single application of the technical grade compound to the eyes of rabbits. Data indicate little acute toxic hazard from accidental ingestion. ENT-20127 did not produce skin sensitivization in guinea pigs. Acute aerosol as well as acute and subchronic saturated vapor inhalation exposures of rats resulted experimentally in no deleterious effect.