Effect of Peritoneal Rewarming on Renal Function in the Hypothermic Dog

Two groups of eight dogs were subjected to an experimentally induced hypothermia of 25 C. One group was rewarmed externally using a circulating water blanket while the other group was rewarmed by peritoneal dialysis. Glomerular filtration rate (GFR), renal blood flow (RBF) and urine flow were reduce...

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Bibliographic Details
Main Authors: Patton,John F, Hamlet,Murray P, Wolfe,Dan L
Format: Report
Language:English
Subjects:
Blood analysis
Blood flow
Cardiovascular system
Clearances
Cryobiology
Dialysis
Dogs
Glomeruli
Heating
Hypothermia
Kidneys
Peritoneal dialysis
Peritoneum
Stress Physiology
Urine
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Summary:Two groups of eight dogs were subjected to an experimentally induced hypothermia of 25 C. One group was rewarmed externally using a circulating water blanket while the other group was rewarmed by peritoneal dialysis. Glomerular filtration rate (GFR), renal blood flow (RBF) and urine flow were reduced while filtration fraction (FF) and the extraction of PAH (EPAH) were increased during hypothermia. Immediately upon rewarming, RBF and GFR remained significantly depressed in both groups when compared to control values. By 12 hours post rewarming, however, the group rewarmed by peritoneal dialysis showed a complete return of GFR and RBF to prehypothermic levels while in the externally rewarmed group these variables remained depressed. The data suggest that peritoneal dialysis is an effective means of core rewarming producing an earlier return of renal function to control levels than the more conventional means of external rewarming. (Author)