Lesions in Guinea Pigs Infected with 'Coxiella burnetii', Strain M-44

Guinea pigs inoculated with the live, M-44 vaccine strain of Coxiella burnetii were examined grossly and microscopically for the presence of Q fever-related lesions. Mild myocarditis was observed in 38% of infected, but in none of the control animals. Livers showed significant incidence of hepatitis...

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Bibliographic Details
Main Authors: Johnson,James W, McLeod,Charles G, Stookey,James L, Higbee,Glen A, Pedersen,Carl E , Jr
Format: Report
Language:English
Subjects:
ATTENUATION
BIOASSAY
COXIELLA BURNETII
GUINEA PIGS
HEART
HISTOLOGY
LABORATORY ANIMALS
LESIONS
LIVE VACCINES
LIVER
Medicine and Medical Research
Microbiology
PATHOLOGY
Q FEVER
RICKETTSIACEAE
SPLEEN
VACCINES
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Summary:Guinea pigs inoculated with the live, M-44 vaccine strain of Coxiella burnetii were examined grossly and microscopically for the presence of Q fever-related lesions. Mild myocarditis was observed in 38% of infected, but in none of the control animals. Livers showed significant incidence of hepatitis, necrosis and granuloma formation, especially during the first eight days of the infection. A much lower incidence of splenitis was also found but was considered to be of borderline significance. Generally, lesions were mild in nature and none seemed to endanger the life of the animal or cause observable distress.