Mutagen and Oncogen Study on 1,1-Dimethylhydrazine

A three tier test was organized into a matrix of assays employing microbial cells, mammalian cells in culture, and in vivo experiments in mice. 1, 1-dimethylhydrazine exhibited genetic activity in several in vitro assays. The responses were consistently obtained under conditions of microsomal enzym...

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Bibliographic Details
Main Authors: Brusick, David, Matheson, Dale W
Format: Report
Language:English
Subjects:
BIOASSAY
DEOXYRIBONUCLEIC ACIDS
GENETICS
HYDRAZINE/1-1-DIMETHYL
IN VITRO ANALYSIS
IN VIVO ANALYSIS
LETHALITY
METHYL HYDRAZINES
MICE
MICROORGANISMS
MUTAGENS
PE61102F
Rocket Propellants
TOXICITY
Toxicology
WUAMRL2312V115
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Summary:A three tier test was organized into a matrix of assays employing microbial cells, mammalian cells in culture, and in vivo experiments in mice. 1, 1-dimethylhydrazine exhibited genetic activity in several in vitro assays. The responses were consistently obtained under conditions of microsomal enzym activation suggesting the formation an active metabolite. The dominant lethal test results were negative.