Preliminary Assessment of Relative Toxicity of Ethyl Centralite (N,N'-Diethylcarbanilide) April 1976 - April 1977

A hazard evaluation of ethyl centralite was performed using rats, rabbits and guinea pigs. Acetone solutions of the technical grade compound produced mild irritation when applied to the intact or abraded skin of rabbits, but the dry material did not. Direct application to rabbit eyes resulted in mil...

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Bibliographic Details
Main Authors: Weeks,Maurice H, McCreesh,Arthur H
Format: Report
Language:English
Subjects:
Ammunition and Explosives
Carbanilide/N-N'-diethyl
Environmental Health and Safety
EYE
GUINEA PIGS
INDUSTRIAL HYGIENE
INHALATION
IRRITATION
MUTAGENS
RABBITS
RATS
SKIN(ANATOMY)
SMOKELESS PROPELLANTS
TOXICITY
Toxicology
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Summary:A hazard evaluation of ethyl centralite was performed using rats, rabbits and guinea pigs. Acetone solutions of the technical grade compound produced mild irritation when applied to the intact or abraded skin of rabbits, but the dry material did not. Direct application to rabbit eyes resulted in mild conjunctival irritation. Data indicated little toxic hazard from accidental ingestion or acute vapor inhalation. In vitro mutagenic studies were negative. It was recommended that personnel handling solid ethyl centralite wear approved eye and skin protective equipment. (Author)