Elevated Glycosyltransferase Activities in Infected or Traumatized Hosts: Nonspecific Response to Inflammation

Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha sub 2 -fucosyltransferase, and alpha sub 3 -fucosyltransferase activity of rat liver. Such changes may reflect an increased demand for glycosylation of acute-phase proteins synthesized...

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Bibliographic Details
Main Authors: Canonico, P G, Little, J S, Powanda, M C, Bostian, K A, Beisel, W R
Format: Report
Language:English
Subjects:
BACTEREMIA
FEVERS
INFECTIOUS DISEASES
INFLAMMATION
LIVER
Medicine and Medical Research
RATS
REPRINTS
RESPONSE(BIOLOGY)
STREPTOCOCCAL PNEUMONIA
TRANSFERASES
TRAUMA
VIRUS DISEASES
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Summary:Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha sub 2 -fucosyltransferase, and alpha sub 3 -fucosyltransferase activity of rat liver. Such changes may reflect an increased demand for glycosylation of acute-phase proteins synthesized and secreted by the liver during inflammatory processes. Serum sialyltransferase became elevated in bacteria-infected or burned rats and sandfly fever-infected humans, but did not correlate with acute-phase serum protein changes. These data suggest that nonparenchymal liver cells, such as macrophages, may contribute substantially to elevated sialyltransferase activity in the circulation during infection and, as such, represent a general host response to infection and tissue trauma. Published in Infection and Immunity, v29 n1 p114-118, Jul 1980.