In Vitro Response of Guinea Pig Peritoneal Macrophages to Legionella pneumophila

Transmission and scanning electron microscopy were used to study the phagocytosis of virulent and avirulent strains of Legionella pneumophila. The interaction between L. pneumophila and peritoneal macrophages from normal guinea pigs or from animals that had survived infection was studied. The virule...

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Bibliographic Details
Main Authors: Kishimoto, R A, White, J D, Shirey, F G, McGann, V G, Berendt, R F
Format: Report
Language:English
Subjects:
BACTERIOPHAGES
ELECTRON MICROSCOPY
GUINEA PIGS
IN VITRO ANALYSIS
LEGIONELLA PNEUMOPHILA
Medicine and Medical Research
PHAGOCYTES
REPRINTS
RESPONSE(BIOLOGY)
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Summary:Transmission and scanning electron microscopy were used to study the phagocytosis of virulent and avirulent strains of Legionella pneumophila. The interaction between L. pneumophila and peritoneal macrophages from normal guinea pigs or from animals that had survived infection was studied. The virulent strains survived and proliferated within the phagocyte after ingestion by either type of macrophage, whereas the avirulent strain of bacteria was killed by normal macrophages. Although the addition of immune serum enhanced phagocytosis, the outcome was the same as with normal serum. Published in Infection and Immunity, v31 n3 p1209-1213, Mar 1981.