An in vitro Method for the Screening of Trichothecene Mycotoxin Cytotoxicity and the Study of Mycotoxin Countermeasures

A thymocytic cell bio-assay was developed for assessing the toxicity of the trichothecene mycotoxin T-2. The in vitro toxicity of mycotoxin T-2 towards mouse mono-nuclear leukocytes prepared from spleen, thymus, peritoneal lavage and bone marrow cells was studied. Bone marrow cells were found to mor...

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Bibliographic Details
Main Authors: DiNinno, V L, Penman, D, Bhatti, A R, Erhardt, N P, Lockwood, P A
Format: Report
Language:English
Subjects:
Anatomy and Physiology
BONE MARROW
CYTOTOXICITY
CYTOTOXINS
FOREIGN REPORTS
IN VITRO ANALYSIS
LEUKOCYTES
MICE
MYCOTOXINS
PERITONEUM
RESISTANCE(BIOLOGY)
SPLEEN
THYMUS
TOXICITY
Toxicology
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Summary:A thymocytic cell bio-assay was developed for assessing the toxicity of the trichothecene mycotoxin T-2. The in vitro toxicity of mycotoxin T-2 towards mouse mono-nuclear leukocytes prepared from spleen, thymus, peritoneal lavage and bone marrow cells was studied. Bone marrow cells were found to more resistant to T-2 toxicity than thymus, spleen and peritoneal cell preparations. This method is rapid and provides consistant and reproducible results for the study of T-2 mycotoxicosis.