Nonspecific Resistance Induced by an Immunopharmacologic Agent Derived from Bordetella pertussis

Administration of Bordetella pertussis vaccine intraperitoneally induces resistance to mouse adenovirus infection. Subcellular fractions of B. pertussis are capable of inducing resistance also. Boivin antigen, a trichloroacetic acid-soluble extract of whole cells, is capable of inducing resistance i...

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Bibliographic Details
Main Authors: Winters, Alvin L, LeBlanc, Paul A, Sloan, Gary L
Format: Report
Language:English
Subjects:
ABSORPTION
ADENOVIRUSES
ALUMS
ANTIGENS
ANTIVIRAL AGENTS
BIOCHEMISTRY
BORDETELLA PERTUSSIS
ENDOTOXINS
IMMUNITY
IMMUNOLOGY
INFECTIOUS DISEASES
LIPOPOLYSACCHARIDES
Medicine and Medical Research
MICE
PE61153N
Pharmacology
POLYACRYLAMIDES
PROTEINS
VACCINES
VIRUS DISEASES
WUNR666028
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Summary:Administration of Bordetella pertussis vaccine intraperitoneally induces resistance to mouse adenovirus infection. Subcellular fractions of B. pertussis are capable of inducing resistance also. Boivin antigen, a trichloroacetic acid-soluble extract of whole cells, is capable of inducing resistance in the dose range of 0.2-2.0 ug when adsorbed to alum. Biochemical analysis of Boivin antigen indicated that the lipopolysaccharide and protein components were not complexed, but were co-extracted. the lipopolysaccharide (endotoxin) moiety was responsible for the antiviral activity and the endotoxin- associated proteins potentiated the antiviral effect.