Comparison of the Effects of Soluble and Particulate Forms of Glucan, an Immunomodulator, on Prostaglandin Synthesis by Rat Peritoneal Macrophages

GLUCAN, AN IMMUNOMODULATOR derived from the yeast Saccharomyces cervesiae, exists in two preparations, particulate (glu-P) and soluble (glu-F). Both preparations enhance host antibacterial and antineoplastic resistance. Unlike glu-F, glu-P is associated with granulomatous reactions within the reticu...

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Bibliographic Details
Main Authors: Bowers, Gary J, Patchen, Myra L, MacVittie, Thomas J, Hirsch, Erwin F, Fink, Mitchell P
Format: Report
Language:English
Subjects:
ANTIBIOTICS
ANTINEOPLASTIC AGENTS
Biochemistry
BIOSYNTHESIS
CHEMOTHERAPEUTIC AGENTS
COMPARISON
ENDOTOXINS
GLUCANS
GRANULOMA
HOSTS(BIOLOGY)
IMMUNITY
PERITONEUM
PHAGOCYTES
Pharmacology
PRODUCTION
PROSTAGLANDIN
RATS
REPRINTS
RESISTANCE(BIOLOGY)
RETICULOENDOTHELIAL SYSTEM
SENSITIVITY
SYNTHESIS
YEASTS
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Summary:GLUCAN, AN IMMUNOMODULATOR derived from the yeast Saccharomyces cervesiae, exists in two preparations, particulate (glu-P) and soluble (glu-F). Both preparations enhance host antibacterial and antineoplastic resistance. Unlike glu-F, glu-P is associated with granulomatous reactions within the reticuloendothelial system (RES) and endotoxin sensitivity. Since some of the adverse effects of glu-P may be mediated by prostaglandins (PGs), we compared the effects of glu-P and glu-F on PG production by rat peritoneal macrophages (PMos). Pub. in American College of Surgeons Surgical Forum, v36 p66-68 1985.