Dermal, Eye and Oral Toxicological Evaluations. Phase II. Acute Oral LD Determinations of Benzothiazole, Dithiane, and Oxathiane

Benzothiazole, dithiane, and oxathiane were administered by oral gavage to groups of 5 male and 5 female Fischer 344 albino rats to establish their oral toxicity (median lethal dose). The oral median lethal dose (LD50) of Benzothiazole was determined to be 493 mg/kg for males, 466 mg/kg for females,...

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Bibliographic Details
Main Authors: Mayhew,Dale A, Muni,Indun A
Format: Report
Language:English
Subjects:
ASA35
BENZENE COMPOUNDS
EYE
IRRITATION
LETHAL DOSAGE
ORAL DOSAGE
ORGANIC SULFUR COMPOUNDS
PE62720A
RATS
SKIN(ANATOMY)
THIAZOLES
TOXICITY
Toxicology
WU059
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Summary:Benzothiazole, dithiane, and oxathiane were administered by oral gavage to groups of 5 male and 5 female Fischer 344 albino rats to establish their oral toxicity (median lethal dose). The oral median lethal dose (LD50) of Benzothiazole was determined to be 493 mg/kg for males, 466 mg/kg for females, and 479 mg/kg for the combined sexes. The oral LD50 of Dithiane was determined to be 3,680 mg/kg for males, 2,768 mg/kg for females, and 3,473 mg/kg for the combined sexes. The oral LD50 of Oxathiane was determined to be 3,328 mg/kg for males, 3,123 mg/kg for the combined sexes. The oral LD50 of Oxathiane for females was estimated to be approximately 3,000 mg/kg. See also Phase 1, AD-B085 904L.