Ischemic-Anoxia of the Central Nervous System: Iron Dependent Oxidative Injury during Reperfusion

This work was begun with the recognition that the current practice of resuscitation from cardiac arrest due to either medical or traumatic causes results in major neurologic injury in 50-80% of resuscitated patients. Only in the last 25 years has there begun to be a systematic examination of the pat...

Full description

Saved in:
Bibliographic Details
Main Authors: White, Blaine C, Krause, Gary S, Aust, Steven D, Kumar, Kusum
Format: Report
Language:English
Subjects:
ANOXIA
AS874
Biochemistry
BRAIN
CALCIUM
CARDIAC ARREST
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
Chloropromazine
Desferoxamine
DOGS
Flunarizine
INHIBITION
IRON
IRREVERSIBLE PROCESSES
ISCHEMIA
LABORATORY ANIMALS
Lidoflazine
LIPIDS
Malondialdehyde
MARKERS
Medicine and Medical Research
MOLECULAR BIOLOGY
MYOCARDIUM
NERVOUS SYSTEM DISEASES
OXIDATION
PARAMETERS
PATHOPHYSIOLOGY
PE62772A
PERFUSION
Peroxidation
PHARMACOLOGICAL ANTAGONISTS
PROTECTION
Reperfusion
RESUSCITATION
SEQUENCES
WOUNDS AND INJURIES
WU264
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This work was begun with the recognition that the current practice of resuscitation from cardiac arrest due to either medical or traumatic causes results in major neurologic injury in 50-80% of resuscitated patients. Only in the last 25 years has there begun to be a systematic examination of the pathophysiology and molecular biology attendant to brain ischemia and reperfusion. The present work continues to examine the sequence of critical events in brain ischemia and reperfusion and tests therapies which may be applied during the reperfusion phase to inhibit the development of biochemical and functional markers of irreversible brain injury. The major products of this work are significant advances in the understanding of the pathophysiology of brain ischemia and reperfusion. During this period, flunarizine (calcium antagonist) and choloropromazine (effects in myocardium include inhibition of both phospholipase and of lipid peroxidation) for protective effects across the injury parameters were examined. Neither flunarizine nor chloropromazine have so far exhibited marked protective effects. Keywords: Dogs; Laboratory animals.