Pyridostigmine Induced Alterations in Rats: Impact of Body Weight and Nifedipine Pretreatment

When rats were injected with pyridostigmine (PYR) based on a mg/kg dosage, lethality appeared to be greater than anticipated when 500g rats were used. Twenty-four hour survival was determined for groups of large and small rats. These animals received a sc injection of either Mestinon equivalent buff...

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Bibliographic Details
Main Authors: Bowers, Wilbert D , Jr, Blaha, Michael, Castro, Iris, Daum, Patricia
Format: Report
Language:English
Subjects:
ANIMALS
ASS15
BLOOD SERUM
BODY WEIGHT
BUFFERS
Chemical, Biological and Radiological Warfare
CHOLINESTERASE
CHOLINESTERASE INHIBITORS
CONTROL
DOSAGE
LETHALITY
MITOCHONDRIA
NIFEDIPINE
PE61102B
Pharmacology
PHYSIOLOGICAL EFFECTS
PYRIDOSTIGMINE
RATS
RESPONSE(BIOLOGY)
WUDA305215
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Summary:When rats were injected with pyridostigmine (PYR) based on a mg/kg dosage, lethality appeared to be greater than anticipated when 500g rats were used. Twenty-four hour survival was determined for groups of large and small rats. These animals received a sc injection of either Mestinon equivalent buffer, 1.8mg or 3.6mg PYR/kg body weight. Serum cholinesterase (ChE) levels were determined for similar doses. With PYR dosage based on mg/kg, small rats were significantly more resistant to PYR than large rats, and also had significantly higher control levels of serum ChE. Keywords: Pyridostigmine; Nifedipine; Cholinesterase; Mitochondria.