Sickle-Cell Trait as a Risk Factor for Sudden Death in Physical Training

Case reports of sudden death during exertion have not established an association between the sickle-cell trait (hemoglobin AS) and exercise-related death. To test this association, all deaths occurring among 2 million enlisted recruits during basic training in the U.S. Armed Forces in 1977 to 1981 w...

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Bibliographic Details
Main Authors: Kark, John A, Posey, David M, Schumacher, Harold R, Ruehle, Charles J
Format: Report
Language:English
Subjects:
AUTOPSY
CLINICAL MEDICINE
DEATH
ENLISTED PERSONNEL
EXERCISE(PHYSIOLOGY)
HEMOGLOBIN
Medicine and Medical Research
MILITARY TRAINING
PHYSICAL FITNESS
RECORDS
RECRUITS
REPRINTS
RISK
SICKLE CELL ANEMIA
Stress Physiology
TRAINING
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Summary:Case reports of sudden death during exertion have not established an association between the sickle-cell trait (hemoglobin AS) and exercise-related death. To test this association, all deaths occurring among 2 million enlisted recruits during basic training in the U.S. Armed Forces in 1977 to 1981 were classified from autopsy and clinical records as non-sudden deaths or as sudden deaths explained or unexplained by preexisting disease. we conclude that recruits in basic training with the sickle-cell trait have a substantially increased, age dependent risk of exercise-related sudden death unexplained by any known preexisting cause. Reprints. Pub in New England Jnl. of Medicine v317 p781-787, 24 Sep 1987.