Mycotoxicosis Caused by Aerosolized T-2 Toxin Administered to Female Mice

Thymus, spleen, adrenal glands, and small intestine of female mice exposed to aerosolized T-2 mycotoxin were examined at postexposure hours (PEH) 0.25, 1,2,4,6,9,12, and 24. Lymphocyte necrosis was observed at PEH 1 in the thymus, spleen, and lamina propria and Peyer patches of the small intestine....

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Bibliographic Details
Main Authors: Thurman, J D, Creasia, D A, Trotter, R W
Format: Report
Language:English
Subjects:
ADRENAL CORTEX
ADRENAL GLANDS
AEROSOLS
CELLS(BIOLOGY)
CONNECTIVE TISSUE
EXPOSURE(PHYSIOLOGY)
FEMALES
LYMPHOCYTES
MICE
MYCOTOXINS
NECROSIS
PHYTOTOXINS
POLYMORPHONUCLEAR NEUTROPHILS
REPRINTS
SMALL INTESTINE
SPLEEN
T-2 TOXINS
THYMUS
TOXIC DISEASES
TOXICITY
Toxicology
TRICHOTHECENES
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Summary:Thymus, spleen, adrenal glands, and small intestine of female mice exposed to aerosolized T-2 mycotoxin were examined at postexposure hours (PEH) 0.25, 1,2,4,6,9,12, and 24. Lymphocyte necrosis was observed at PEH 1 in the thymus, spleen, and lamina propria and Peyer patches of the small intestine. Necrosis of small intestinal crypt epithelial cells was observed at PEH 2, and necrosis of parenchymal cells and increased number of neutrophils were seen in sinusoids of the adrenal cortex at PEH 4. These results indicated that the earliest microscopic evidence of T-2 mycotoxicosis after aerosol exposure was necrosis of lymphocytes in the thymus, spleen, and lamina propria and Peyer patches of the small intestine. Keywords: Phytotoxins, Toxic disease, Reprints.