Topical Hazard Evaluation Program (THEP) Assessment of the Relative Toxicity of Candidate Insect Propellents AI3-38306, AI3-38315, AI3-38530, AI3- 39041, AI3-39076, AI3-39077, AI3-39078, AI3-39085, U.S. Department of Agricultural Proprietary Chemicals Study Numbers, 75-51-0623-89, 75-51-0624-89, 75-51-0625-89, 75-51-0626-89, 75-51-0627-89, 75-51-0628-89, 75-51-0629-89, 75- 510630-89

The purpose of the Topical Hazard Evaluation Program (THEP) is to investigate relevant health endpoints of proposed insect repellent chemicals. Data from these studies are used to recommend the course of further entomological and toxicological evaluations with subject chemicals. The results from the...

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Bibliographic Details
Main Author: Weeks, Maurice H
Format: Report
Language:English
Subjects:
ALLERGIC DISEASES
ANIMALS
CHEMICALS
HAZARDS
INSECT REPELLENTS
NUMBERS
RESPONSE
SENSITIZING
SKIN ANATOMY
TEST AND EVALUATION
TOPICAL HAZARD EVALUATION PROGRAM (THEP)
TOXICITY
Toxicology
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Summary:The purpose of the Topical Hazard Evaluation Program (THEP) is to investigate relevant health endpoints of proposed insect repellent chemicals. Data from these studies are used to recommend the course of further entomological and toxicological evaluations with subject chemicals. The results from the current animal sensitization studies showed that two of the eight test compounds AI3-39076 and AI3-39077 have some potential for causing an allergic response in man. A positive result from a sensitization test is a prime basis for rejecting a material as a topical insect repellent. The results from the overall battery of biological tests showed that the candidate inset repellents AI3-38530, AI3-39041, and AI3-39078 produced relatively unremarkable toxicological responses. Also available as Rept. Nos. USAEHA-75-51-0627-89 thru USAEHA-75-51-0630-89.