Drug Evaluation in the Plasmodium Falciparum - Aotus Model

Infections in Aotus trivirgatus of two strains of Plasmodium falciparum, Uganda Palo Alto (chloroquine-sensitive) or Vietnam Smith (chloroquine-resistant), or the New Guinea-Chesson strain of P. vivax, were used to assess the blood schizonticidal/curative activity of experimental antimalarial drugs....

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Bibliographic Details
Main Author: Rossan, Richard N
Format: Report
Language:English
Subjects:
ANTIMALARIALS
ANTIPARASITIC DRUGS
ANTISCHISTOSOMALS
AS870
DOSAGE
DRUGS
INFECTIOUS DISEASES
OSMOSIS
OWL MONKEYS
PARASITEMIAS
PE62770A
Pharmacology
PLASMODIUM FALCIPARUM
PUMPS
QUINOLINES
SODIUM
TEST AND EVALUATION
VIETNAM
WR245982
WU028
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Summary:Infections in Aotus trivirgatus of two strains of Plasmodium falciparum, Uganda Palo Alto (chloroquine-sensitive) or Vietnam Smith (chloroquine-resistant), or the New Guinea-Chesson strain of P. vivax, were used to assess the blood schizonticidal/curative activity of experimental antimalarial drugs. WR 245082, an acridineamine, at similar doses cured infections of chloroquinesensitive and resistant P. falciparum strains. Three 8- aminoquinolines cured trophozoite-induced infections of P. vivax. A quinoline, WR 247705, cured Uganda Palo Alto strain infections. WR 251853 was ineffective against Uganda Palo Alto parasitemias. Injection of desferrioxamine plus osmotic pump only cleared parasitemia. WR 250547, an acridinol, cured blood-induced infections of P. vivax. WR 250547 and WR 250548 administered in combination against Vietnam Smith infections a potentiating antimalarial effect was observed. WR 122455 cured all previous treatment failures and also primary infections. Sodium artesunate suppressed an Uganda Palo Alto parasitemia. Keywords: Antimalarials; Antiparasitic drugs.