Antibodies to Liposomes, Phospholipids, and Cholesterol, Implications for Autoimmunity, Atherosclerosis and Aging

It is often stated that lipids are are nonimmunogenic; however, this idea is now known to be a false presumption. Polyclonal antibodies having considerable specificity for individual phospholipid constituents of liposomes have now also been developed (Wassef et al., 1989; Banerji and Alving, 1989)....

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Bibliographic Details
Main Author: Alving, Carl R
Format: Report
Language:English
Subjects:
ADULTS
ANIMALS
ANTIBODIES
ATHEROSCLEROSIS
AUTOIMMUNIZATION
Biochemistry
BLOOD SERUM
CHOLESTEROL
HUMANS
IMMUNOASSAY
LIPIDS
LIPOSOMES
PHOSPHOLIPIDS
REPRINTS
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Summary:It is often stated that lipids are are nonimmunogenic; however, this idea is now known to be a false presumption. Polyclonal antibodies having considerable specificity for individual phospholipid constituents of liposomes have now also been developed (Wassef et al., 1989; Banerji and Alving, 1989). After developing immunoassay procedures (complement-dependent assays and solid- phase immunosorbent assays) for detecting antibodies to lipids, we and others discovered that naturally-occurring autoantibodies to various phospholipids are widespread and occur in most adult animal or human sera. Pub. in Horizons in Membrane Biotechnology, 941-51 1990.