Natural History of HTLV III Infection in USAF Personnel: Clinical Evaluation, Laboratory Evaluation, Assessment of In Vivo and In Vitro Immunologic Status, and Data Storage

The Wilford Hall USAF Center HIV Scientific Study Group has continued our investigation into the Natural History of HIV disease in active duty USAF personnel and their dependents with intensive immunological evaluation and staging according to the Walter Reed staging classification. Significant prog...

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Bibliographic Details
Main Authors: Boswell, R N, Zajac, Robert A
Format: Report
Language:English
Subjects:
ACTIVE DUTY
CLASSIFICATION
CLINICAL MEDICINE
DATA STORAGE SYSTEMS
DISEASES
FAMILY MEMBERS
HTLV(HUMAN T LYMPHOTROPIC VIRUS)
HTLV- III
HUMAN IMMUNODEFICIENCY VIRUSES
IMMUNITY
IMMUNOLOGY
IN VIVO ANALYSIS
LABORATORY TESTS
LYMPHOCYTES
Medicine and Medical Research
NATURAL HISTORY
NEUROLOGY
NUMBERS
PE63105A
REED VALVES
RESPONSE(BIOLOGY)
STAGING
TEST AND EVALUATION
WU024
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Summary:The Wilford Hall USAF Center HIV Scientific Study Group has continued our investigation into the Natural History of HIV disease in active duty USAF personnel and their dependents with intensive immunological evaluation and staging according to the Walter Reed staging classification. Significant progression over 12 months of observation appears to be approximately 10%. Studies to determine a marker of disease progression other than absolute CD4a lymphocyte counts are ongoing. Our large neurological natural history study has continued on all active duty HIV-seropositive individuals and they continue to receive full neurological evaluations as well as CSF analysis. Our data demonstrate that the CSF immune response is maximal in early-stage HIV disease and more blunted with respect to both absolute CSF lymphocyte numbers and B-cell immunologic response when CD4a counts drop below 400 cells/mm3. Keywords: HTLV III/HIV Natural history; HIV Disease progression; USAF Active duty military HIV, HIV Neurological disease; RAI; Prognostic markers of disease progression. (jes)