Drug Evaluation in the Plasmodium falciparum - Aotus Model

The objective of these studies was to evaluate experimental antimalarial drugs in the Panamanian night monkey (Aotus 1. lemurinus) experimentally infected with Plasmodium falciparum. Four folic acid inhibitors were tested against infections of the pyrimethamine-resistant Vietnam Smith strain. Of the...

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Bibliographic Details
Main Author: Rossan, Richard N
Format: Report
Language:English
Subjects:
ANTIMALARIALS
ARTIMISININ DERIVATIVES
AS870
CHLOROQUINE
CHLOROQUINE RESISTANCE
DRUGS
FOLIC ACID
FOLIC ACID INHIBITORS
INFECTIOUS DISEASES
INHIBITORS
Medicine and Medical Research
MONKEYS
NIGHT
PANAMA
PARASITEMIAS
PE62787A
PLASMODIUM FALCIPARUM
PYRIMETHAMINE
RESISTANCE(BIOLOGY)
TEST AND EVALUATION
VIETNAM
WUDA312790
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Summary:The objective of these studies was to evaluate experimental antimalarial drugs in the Panamanian night monkey (Aotus 1. lemurinus) experimentally infected with Plasmodium falciparum. Four folic acid inhibitors were tested against infections of the pyrimethamine-resistant Vietnam Smith strain. Of the four drugs evaluated, pyrimethamine, proguanil, cycloguanil, and a proguanil analog (WR 250417), only the proguanil analog had antimalarial activity. A total 3.0 mg/kg dose cured infections in 3 to 7 treatments, a 30.0 mg/kg total dose cured 6 infections out of 8 treatments, and a total dose of 150.0 mg/kg cured infections in 4 of 4 treatments. Six calcium channel blockers were administered with chloroquine in trials to reverse chloroquine-resistance in vivo of Vietnam Smith/RE infections. Only desipramine cleared primary parasitemias but did not cure infections.