Development of a Screening Procedure for Use in the Evaluation of Topical Protectants after Challenge with Vesicating Agents

1,1' -Thiobis2-cloroethane (bis(2-chloroethyl)sulfide, sulfur mustard, H) causes skin, respiratory and eye injury land has been identified as being mutagenic and carcinogenic. The development of topical protectants that can decrease the effects of cutaneous exposure to vesicating chemical warfa...

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Bibliographic Details
Main Authors: Forster, Jeffry S, Jacinto, Brenda, Gadson, Curtis, Mershon, Millard M
Format: Report
Language:English
Subjects:
ARMY PERSONNEL
AS875
CHEMICAL AGENTS
CHLOROVINYLDICHLORO ARSINE
DECONTAMINATION
EXPOSURE(GENERAL)
EYE
IN VIVO ANALYSIS
LAND AREAS
LEWISITE
LIMITATIONS
Military Operations, Strategy and Tactics
MUSTARD
MUSTARD AGENTS
PE62787A
PENETRATION
RESPIRATORY SYSTEM
SCREENING PROCEDURE
SKIN DISEASES
SULFUR
TOPICAL PROTECTANTS
WOUNDS AND INJURIES
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Summary:1,1' -Thiobis2-cloroethane (bis(2-chloroethyl)sulfide, sulfur mustard, H) causes skin, respiratory and eye injury land has been identified as being mutagenic and carcinogenic. The development of topical protectants that can decrease the effects of cutaneous exposure to vesicating chemical warfare agents or that may enhance the effectiveness of decontamination through limiting penetration to the skin should significantly enhance a soldier's ability to carry out his or her job in a chemically hostile environment. Preliminary in vivo studies with a small number of candidate topical protectants demonstrated that they could provide protection against several different chemical agents.