Bacteria-Phagocyte Interactions: Emerging Tactics in an Ancient Rivalry

Although phagocytes appear to have a redundancy of both oxidative and non-oxidative killing mechanism, nevertheless, bacterial pathogens are still able to evade these defenses in vivo and cause lethal infection. As the mechanisms by which phagocytes function have become detailed at the molecular lev...

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Bibliographic Details
Main Authors: Cross, Alan S, Kelly, Niamh M
Format: Report
Language:English
Subjects:
BACTERIA
DEFENSE SYSTEMS
FUNCTIONS
IN VIVO ANALYSIS
INFECTIOUS DISEASES
LETHALITY
Medicine and Medical Research
MOLECULAR STATES
OXIDATION
PATHOGENIC MICROORGANISMS
PHAGOCYTES
REDUNDANCY
REPRINTS
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Summary:Although phagocytes appear to have a redundancy of both oxidative and non-oxidative killing mechanism, nevertheless, bacterial pathogens are still able to evade these defenses in vivo and cause lethal infection. As the mechanisms by which phagocytes function have become detailed at the molecular level, both the recognition of specific bacterial virulence determinants and their effects at specific sites in the phagocyte are also being identified. Knowledge of these interactions may permit the use of immunomodulators either to neutralize theses virulence determinants or to enhance the bactericidal capabilities of the phagocyte. Availability: Pub. in FEMS Microbiology Immunology, v64 p245-258 1990.