An Investigation Concerning the Potential for use of Polylactic/Polyglycolic Acid Confluent Sheets in the Treatment of Osseous Defects

Polylactic/polyglycolic acid combinations (alpha polyamides) are biodegradable materials commonly used in suture materials and surgical meshes for the temporary support of abdominal organs. The materials are well known in the clinical literature and have been in common usage without risk for over tw...

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Bibliographic Details
Main Authors: Cobb, Charles M, Solano, Caesar E, Reed, John C, Hiatt, Robert W
Format: Report
Language:English
Subjects:
BIODEGRADATION
COPOLYMERS
GLYCOLIC ACID
GRAFT POLYMERIZATION
HISTOLOGY
LACTIC ACID
Medicine and Medical Research
OSSEOUS TISSUES
Plastics
POLYAMIDE PLASTICS
POLYGLYCOLIC ACID
POLYLACTIC ACID
Polymer Chemistry
SURGICAL SUPPLIES
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Summary:Polylactic/polyglycolic acid combinations (alpha polyamides) are biodegradable materials commonly used in suture materials and surgical meshes for the temporary support of abdominal organs. The materials are well known in the clinical literature and have been in common usage without risk for over two decades. The polyamides are rich in polyester linkages that are degraded in aqueous environments by hydrolysis. Various investigators have shown that the pure form of polyglycolic acid (PGA) degrades over a period of 5 months whereas pure polylactic acid (PLA) takes about 6.5 months. Copolymers of PLA/PGA have been synthesized that degrade within a few weeks to several months depending upon the ratios employed and the specific sequencing of the chemical units. Further, the alpha polyamides show no adverse host tissue reactions when implanted in numerous animal models.