Isolation Suppresses Both Immune and Neuroendocrine Functioning and Decreases the Locomotor Activity of Normal and Immunosuppressed C3H/HeN Mice

This inter-disciplinary experiment examined the dramatic influence that environmental variables can have on behavioral, neuroendocrine, and immune system parameters. In this study, we examined the effects of housing on locomotion, circulating lymphocytes, and catecholamines (i.e., Norepinephrine N a...

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Bibliographic Details
Main Authors: Collins, Daniel L, Cohen, Stuart J, Gruber, Dale F, D'Alesandro, Michelle M, Mickley, G A
Format: Report
Language:English
Subjects:
BEHAVIORAL SCIENCES
Biochemistry
CATECHOLAMINES
EPINEPHRINE
FEMALES
IMMUNOSUPPRESSION
ISOLATION
LOCOMOTION
LYMPHOCYTES
MICE
NEUROENDOCRINE
NOREPINEPHRINE
PARAMETERS
Psychology
RADIATION
VARIABLES
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Summary:This inter-disciplinary experiment examined the dramatic influence that environmental variables can have on behavioral, neuroendocrine, and immune system parameters. In this study, we examined the effects of housing on locomotion, circulating lymphocytes, and catecholamines (i.e., Norepinephrine N and Epinephrine E) of 12-week-old female C3H/HeN mice. Ten week old female C3H/HeN mice (10/group) were either immunocompromised (following 0.5 Gy or 4.5 Gy 60Co gamma irradiation) or normal (sham-irradiated), and were housed in isolation (1/cage) or groups (10/cage) for 25 days following radiation exposure. All dependent variables were obtained on day 25 postirradiation. Isolation, Immune System, Neuroendocrine, Locomotor activity, Immunosuppression.