The Effects of Platelet-Activating Factor (PAF) and a PAF Antagonist (CV-3988) on Smoke Inhalation Injury in an Ovine Model

The role of platelet-activating factor (PAF) in inhalation injury was studied in sheep, using CV-3988, a PAF antagonist. Following smoke exposure, 15 sheep were divided into three groups of five. Group I animals were untreated; group 11 animals were treated with CV-3988 before and after exposure; gr...

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Bibliographic Details
Main Authors: Ikeuchi, Hisashi, Sakano, Tsutomu, Sanchez, Jose, Mason, Arthur D , Jr, Pruitt, Basil A , Jr
Format: Report
Language:English
Subjects:
ANIMALS
ANTAGONISTS
BENEFITS
BLOOD
BLOOD CIRCULATION
BLOOD MALONDIALDEHYDE
BLOOD PLATELETS
BURNS(INJURIES)
CELLS
FLUIDS
INHALATION
LIPIDS
MANAGEMENT
MEAN
Medicine and Medical Research
MODULATION
PATHOPHYSIOLOGY
Pharmacology
PLATELET ACTIVATING FACTOR
SHEEP
SMOKE
SMOKE INHALATION
TOXICITY
WOUNDS AND INJURIES
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Summary:The role of platelet-activating factor (PAF) in inhalation injury was studied in sheep, using CV-3988, a PAF antagonist. Following smoke exposure, 15 sheep were divided into three groups of five. Group I animals were untreated; group 11 animals were treated with CV-3988 before and after exposure; group III animals were treated only after exposure. In group I, platelet and WBC counts were markedly changed within 6 hours (p 0.05); in the treated groups, alteration of cell counts was not obvious. Blood malondialdehyde (MDA) levels were increased significantly only in group I. Blood PGE2 and TXB2 levels did not differ among the groups. Mean tissue MDA and mean bronchoalveolar lavage fluid (BALF) MDA concentrations were significantly increased in group I (p 0.01); mean BALF TXB2 levels were significantly decreased in group I (p 0.01). These data suggest that PAF affects inhalation injury through modulation of lipid oxygenation and that PAF antagonists may offer therapeutic benefit in the management of this injury.