Increased Vascular Resistance with Hemoglobin-Based Oxygen Carriers

Purpose: To compare the effects of resuscitation with hemoglobin- based oxygen-carriers and conventional crystalloid and colloid resuscitation fluids on hemodynamics, oxygen transport, and oxygen consumption in an animal model of the field medical use of these fluids in the treatment of hemorrhagic...

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Bibliographic Details
Main Authors: Hess, J R, MacDonald, V W, Gomez, C S, Copper, V
Format: Report
Language:English
Subjects:
ALBUMINS
Anatomy and Physiology
BLOOD CELLS
BLOOD SUBSTITUTES
BODY FLUIDS
CARDIOVASCULAR SYSTEM
COLLOIDS
CONSUMPTION
ENDOTHELIUM
FLUIDS
HEMODYNAMICS
HEMOGLOBIN
HEMORRHAGIC SHOCK
HYPERTENSION
LACTATES
MEASUREMENT
MEDICAL RESEARCH
Medicine and Medical Research
OXYGEN CONSUMPTION
PE61102A
PULMONARY BLOOD CIRCULATION
RESISTANCE(BIOLOGY)
RESUSCITATION
TRANSPORT
VASOCONSTRICTING
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Summary:Purpose: To compare the effects of resuscitation with hemoglobin- based oxygen-carriers and conventional crystalloid and colloid resuscitation fluids on hemodynamics, oxygen transport, and oxygen consumption in an animal model of the field medical use of these fluids in the treatment of hemorrhagic shock. Protocol: Twenty-eight immature swine were surgically prepared, allowed to recover five days, water deprived for 48 hours, hemorrhaged of 25 m1/kg over one hour, resuscitated promptly with 1) Ringer's lactate, 75 m1/kg, 2) 7% albumin in Ringer's acetate, 25 m1/kg, 3) 9% unmodified hemoglobin in Ringer's acetate, 25 ml/kg, or 4) 9% alpha alpha-crosslinked hemoglobin in Ringer's acetate, 25 ml/kg, observed with three hours of hemodynamic and oxygen transport measurements, and, finally, blood which had been removed previously was returned.