Hematological Effects of 7.5% NaC1/6% Dextran-70 (HSD) in Rabbits and Pigs

The present study furthers our evaluation of the hematological effects of 7.5% NaC1/6% Dextran (IISD). Blood was obtained from both euvolemic and hemorrhaged rabbits and pigs at times up to 7 d after infusion of 4 ml/kg HSD. Complete blood counts and platelet concentrations were determined, and qual...

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Bibliographic Details
Main Authors: Dubick, Michael A, Summary, James J
Format: Report
Language:English
Subjects:
Anatomy and Physiology
ANEMIAS
BLOOD CELLS
BLOOD COAGULATION
BLOOD COUNTS
BLOOD PLASMA
BLOOD PLATELETS
BLOOD VOLUME
CARDIOVASCULAR SYSTEM
DEXTRAN
EXPANSION
HEMATOCRIT
HEMATOLOGY
HEMOGLOBIN
HEMORRHAGE
HEMORRHAGIC SHOCK
HYPOTENSION
INFUSIONS
INTENSITY
LEUKOCYTES
LYMPHOCYTES
MEDICAL RESEARCH
Medicine and Medical Research
MONOCYTES
MORPHOLOGY
OBSERVATION
Pharmacology
PHYSIOLOGICAL EFFECTS
VOLUME
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Summary:The present study furthers our evaluation of the hematological effects of 7.5% NaC1/6% Dextran (IISD). Blood was obtained from both euvolemic and hemorrhaged rabbits and pigs at times up to 7 d after infusion of 4 ml/kg HSD. Complete blood counts and platelet concentrations were determined, and qualitative red blood cell (RBC) morphology was evaluated. In both species changes in hematocrit, hemoglobin, RBC, and platelet concentrations reflected the degree of hemorrhage and the subsequent plasma volume expansion induced by HSD. Infusion of HSD did not significantly affect mean corpuscular volume, mean corpuscular hemoglobin or mean corpuscular hemoglobin concentration and was consistent with the lack of significant morphological changes in RBC size, shape and staining intensity. Interestingly, a transient increase in white blood cell concentrations was observed, and at 2 to 4 hr after HSD infusion, a marked increase in segmented neutrophils was observed. In general, these data do not suggest any HSD-induced anemia, but they do support other observations that HSD infusion should have minimal effects on hemostasis... Rabbits, Pigs, Red blood cells, White blood cells, Platelets, Hematocrit