Cessation of Focal Epileptiform Activity Using Cortical Calcium Blocker

60-80 POUND MALE PIGS WERE SUBJECTED TO GENERAL ANESTHESIA, USING A BALANCED NARCOTIC TECHNIQUE (FENTANYL). The animals were then subjected to removal of the entire flat surface of the calvarium, as well as the dura (aside from the superior sagittal sinus). A cortical electroencephalographic (EEG) g...

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Bibliographic Details
Main Authors: Bergman, William C, Moores, Leon E
Format: Report
Language:English
Subjects:
ANESTHESIA
ANIMALS
ANTICONVULSANTS
BRAIN
CALCIUM
CALCIUM CHANNEL BLOCKERS
DURA MATER
ELECTROENCEPHALOGRAPHY
EPILEPTIFORM ACTIVITY
EXPOSURE(GENERAL)
GRIDS
Medicine and Medical Research
NARCOTICS
NIMODIPINE
PENICILLINS
PHARMACOLOGICAL ANTAGONISTS
Pharmacology
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Summary:60-80 POUND MALE PIGS WERE SUBJECTED TO GENERAL ANESTHESIA, USING A BALANCED NARCOTIC TECHNIQUE (FENTANYL). The animals were then subjected to removal of the entire flat surface of the calvarium, as well as the dura (aside from the superior sagittal sinus). A cortical electroencephalographic (EEG) grid (PMT Corp.) was then placed over the surface of the exposed brain. Through a 3mm. hole in the grid, a seizure focus was established, using penicillin (5,000,000 U/cc.). Once this was definitively established, the penicillin was removed and replaced with a calcium channel blocker (nimodipine). In two out of four procedures, the focal epileptiform activity was ameliorated or altered.