Cessation of Focal Epileptiform Activity Using Cortical Calcium Blocker

60-80 POUND MALE PIGS WERE SUBJECTED TO GENERAL ANESTHESIA, USING A BALANCED NARCOTIC TECHNIQUE (FENTANYL). The animals were then subjected to removal of the entire flat surface of the calvarium, as well as the dura (aside from the superior sagittal sinus). A cortical electroencephalographic (EEG) g...

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Main Authors: Bergman, William C, Moores, Leon E
Format: Report
Language:English
Subjects:
ANESTHESIA
ANIMALS
ANTICONVULSANTS
BRAIN
CALCIUM
CALCIUM CHANNEL BLOCKERS
DURA MATER
ELECTROENCEPHALOGRAPHY
EPILEPTIFORM ACTIVITY
EXPOSURE(GENERAL)
GRIDS
Medicine and Medical Research
NARCOTICS
NIMODIPINE
PENICILLINS
PHARMACOLOGICAL ANTAGONISTS
Pharmacology
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Moores, Leon E
description 60-80 POUND MALE PIGS WERE SUBJECTED TO GENERAL ANESTHESIA, USING A BALANCED NARCOTIC TECHNIQUE (FENTANYL). The animals were then subjected to removal of the entire flat surface of the calvarium, as well as the dura (aside from the superior sagittal sinus). A cortical electroencephalographic (EEG) grid (PMT Corp.) was then placed over the surface of the exposed brain. Through a 3mm. hole in the grid, a seizure focus was established, using penicillin (5,000,000 U/cc.). Once this was definitively established, the penicillin was removed and replaced with a calcium channel blocker (nimodipine). In two out of four procedures, the focal epileptiform activity was ameliorated or altered.
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The animals were then subjected to removal of the entire flat surface of the calvarium, as well as the dura (aside from the superior sagittal sinus). A cortical electroencephalographic (EEG) grid (PMT Corp.) was then placed over the surface of the exposed brain. Through a 3mm. hole in the grid, a seizure focus was established, using penicillin (5,000,000 U/cc.). Once this was definitively established, the penicillin was removed and replaced with a calcium channel blocker (nimodipine). 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source DTIC Technical Reports
subjects ANESTHESIA
ANIMALS
ANTICONVULSANTS
BRAIN
CALCIUM
CALCIUM CHANNEL BLOCKERS
DURA MATER
ELECTROENCEPHALOGRAPHY
EPILEPTIFORM ACTIVITY
EXPOSURE(GENERAL)
GRIDS
Medicine and Medical Research
NARCOTICS
NIMODIPINE
PENICILLINS
PHARMACOLOGICAL ANTAGONISTS
Pharmacology
title Cessation of Focal Epileptiform Activity Using Cortical Calcium Blocker
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