Development of Novel Models for Describing Multiple Toxicity Effects

Models of additive and independent response of biological systems to mixtures of chemical agents have been modified to incorporate interactive (e.g., synergistic, or antagonistic) response. Computer programs to fit these models to experimental data have been developed. An extensive literature review...

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Bibliographic Details
Main Authors: Haas, Charles N, Frank, Maurice J
Format: Report
Language:English
Subjects:
ADDITIVES
BIOLOGY
CHEMICAL AGENTS
CHEMICALS
COMPUTER PROGRAMS
DATA BASES
EXPERIMENTAL DATA
LITERATURE SURVEYS
MIXTURES
PE61102F
RESPONSE
TOXICITY
Toxicology
WUAFOSR2312AS
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Summary:Models of additive and independent response of biological systems to mixtures of chemical agents have been modified to incorporate interactive (e.g., synergistic, or antagonistic) response. Computer programs to fit these models to experimental data have been developed. An extensive literature review was conducted to obtain data that could be used to test these models. A synoptic review of these data sets is presented. The models developed have, in general, provided an adequate degree of description of the behavior of the chemical mixtures in biological systems. The computer programs could be used for the analysis of data obtained in future experiments.