Mismatch Negativity (MMN) Indexes Subclinical Neurological Differences in HIV Patients during Rapid Perceptual Processing

Thirteen asymptomatic HIV-infected (HIV+) and 13 healthy control (HIV-) subjects were instructed to detect 'oddball'; target tones from among a sequence of nontarget tones delivered rapidly (3 tones/sec) in one ear while ignoring a similar sequence delivered simultaneously in the opposite...

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Bibliographic Details
Main Authors: Linnville, Steven E, Elliott, F. S
Format: Report
Language:English
Subjects:
AUDIO TONES
CELLS(BIOLOGY)
CENTRAL NERVOUS SYSTEM
CLINICAL MEDICINE
EAR
ERPP(EVENT RELATED POTENTIALS)
HEAD(ANATOMY)
HUMAN IMMUNODEFICIENCY VIRUSES
INFECTIOUS DISEASES
MACROPHAGE CELLS
Medical Facilities, Equipment and Supplies
Medicine and Medical Research
MMN(MISMATCH NEGATIVITY)
MONITORING
PE61305A
PERCEPTION
PERIPHERAL NEUROPATHY
PROCESSING
PSYCHOMOTOR SPEED
SEQUENCES
SIGNS AND SYMPTOMS
SKIN(ANATOMY)
STIMULI
VERBAL MEMORAY
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Summary:Thirteen asymptomatic HIV-infected (HIV+) and 13 healthy control (HIV-) subjects were instructed to detect 'oddball'; target tones from among a sequence of nontarget tones delivered rapidly (3 tones/sec) in one ear while ignoring a similar sequence delivered simultaneously in the opposite ear. Event-related potentials (ERPs) to all stimuli were recorded from midline scalp sites. Both groups produced ERP correlates, termed the mismatch negativity (MMN), to the oddball tones during delivery. However, the HIV+ group produced MMNs that were different in morphology to the HIV- group, suggesting that HIV may alter attentional perceptual processing. These results suggested that auditory ERPs elicited by rapid, dichotic stimulus presentations may be useful tools in monitoring subclinical effects of HIV-related neuropathology on perceptual processing.