Genetic Epidemiology of in situ Breast Cancer

This four-year project will define risk factors associated with BCIS through the mechanism of a case/control study. The study population will include approximately 1100-1200 cases of female breast carcinoma in situ and 1100-1200 age-matched female controls selected from the population of the state o...

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Bibliographic Details
Main Author: Claus, Elizabeth B
Format: Report
Language:English
Subjects:
ANATOMICAL SAMPLES
Anatomy and Physiology
BCIS(BREAST CANCER IN SITU)
Biochemistry
BREAST CANCER
CASE STUDIES
CONNECTICUT
CONTRACEPTION
EPIDEMIOLOGY
FERTILITY
Genetic Engineering and Molecular Biology
GENETICS
HISTORY
HORMONES
INTERVIEWING
MAMMARY GLANDS
MEDICAL HISTORY
Medicine and Medical Research
MENSTRUATION
NEOPLASMS
ORAL INTAKE
P53
PARAFFIN BLOCKS GENETIC EPIDEMIOLOGY
POPULATION
PREGNANCY
RISK
TISSUE BANKS
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Description
Summary:This four-year project will define risk factors associated with BCIS through the mechanism of a case/control study. The study population will include approximately 1100-1200 cases of female breast carcinoma in situ and 1100-1200 age-matched female controls selected from the population of the state of Connecticut. At the end of year three, 1262 eligible cases and 1042 eligible controls have been identified. Physicians have consented for 94% of eligible cases. Ninety percent of contacted eligible cases and 86% of contacted eligible controls have agreed to participate in telephone interviews which collect information concerning family history of cancer, pregnancy and menstrual history, hormone replacement therapy, oral contraceptive use, fertility drug use, as well as sociodemographic variables. Preliminary analyses suggest a statistically significant increase in the risk of breast carcinoma in-situ for women with a family history of breast cancer relative to women without such a history. In addition to the interview portion, this study will form a tissue repository consisting of paraffin-embedded tumor tissue collected from a subset of the cases. The expression of two of the most frequently reported oncogenes associated with invasive breast cancer, p53 and c-erbB-2, as well as ER and PR will be examined in these BCIS cases for the first time in a population-based series.