Prediction of Malignancy in Breast Tumors Using Diffusion Weighted Magnetic Resonance Imaging

The purpose of this research is to develop a non-invasive predictor of malignancy in breast tumors using novel magnetic resonance imaging (MRI) techniques. The hypothesis is that the spatial distribution of microvasculature around a breast lesion is specific for malignancy and can be reliably measur...

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Bibliographic Details
Main Authors: Gareau, Paul, Rutt, Brian K
Format: Report
Language:English
Subjects:
ANGIOGENESIS
BREAST CANCER
DIAGNOSIS(MEDICINE)
HIGH STRENGTH GRADIENT COILS
HYPOTHESES
LESIONS
MAGNETIC RESONANCE IMAGING
MALIGNANT
MAMMARY GLANDS
Medicine and Medical Research
MICROVESSEL
Radiobiology
RESPONSE(BIOLOGY)
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Summary:The purpose of this research is to develop a non-invasive predictor of malignancy in breast tumors using novel magnetic resonance imaging (MRI) techniques. The hypothesis is that the spatial distribution of microvasculature around a breast lesion is specific for malignancy and can be reliably measured by a completely non-invasive MRI method. This hypothesis is being tested by: (1) The design and construction of ultra-high gradient coils for MRI. (2) The implementation of advanced MRI pulse sequences for mapping of microvascular parameters, and (3) The correlation of MRI-derived vascular parameters (diffusion and perfusion) with histological parameters (tumor grade and microvessel density) in an animal model of human breast cancer.