Prediction of Malignancy in Breast Tumors Using Diffusion Weighted Magnetic Resonance Imaging

The purpose of this research is to develop a non-invasive predictor of malignancy in breast tumors using novel magnetic resonance imaging (MRI) techniques. The hypothesis is that the spatial distribution of microvasculature around a breast lesion is specific for malignancy and can be reliably measur...

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Main Authors: Gareau, Paul, Rutt, Brian K
Format: Report
Language:English
Subjects:
ANGIOGENESIS
BREAST CANCER
DIAGNOSIS(MEDICINE)
HIGH STRENGTH GRADIENT COILS
HYPOTHESES
LESIONS
MAGNETIC RESONANCE IMAGING
MALIGNANT
MAMMARY GLANDS
Medicine and Medical Research
MICROVESSEL
Radiobiology
RESPONSE(BIOLOGY)
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Rutt, Brian K
description The purpose of this research is to develop a non-invasive predictor of malignancy in breast tumors using novel magnetic resonance imaging (MRI) techniques. The hypothesis is that the spatial distribution of microvasculature around a breast lesion is specific for malignancy and can be reliably measured by a completely non-invasive MRI method. This hypothesis is being tested by: (1) The design and construction of ultra-high gradient coils for MRI. (2) The implementation of advanced MRI pulse sequences for mapping of microvascular parameters, and (3) The correlation of MRI-derived vascular parameters (diffusion and perfusion) with histological parameters (tumor grade and microvessel density) in an animal model of human breast cancer.
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source DTIC Technical Reports
subjects ANGIOGENESIS
BREAST CANCER
DIAGNOSIS(MEDICINE)
HIGH STRENGTH GRADIENT COILS
HYPOTHESES
LESIONS
MAGNETIC RESONANCE IMAGING
MALIGNANT
MAMMARY GLANDS
Medicine and Medical Research
MICROVESSEL
Radiobiology
RESPONSE(BIOLOGY)
title Prediction of Malignancy in Breast Tumors Using Diffusion Weighted Magnetic Resonance Imaging
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