Development of Quantitative Microvascular Breast MRI

The purpose of this research is to develop a non-invasive predictor of malignancy in breast tumors through the design and preliminary validation of a new form of magnetic resonance imaging (MRI) . The hypothesis is that the spatial distribution of microvasculature around a solid breast lesion is spe...

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Bibliographic Details
Main Author: Rutt, Brian
Format: Report
Language:English
Subjects:
ANATOMICAL MODELS
BREAST CANCER
HIGH RESOLUTION
HYPOTHESES
LESIONS
MAGNETIC RESONANCE IMAGING
MAMMARY GLANDS
MAPPING
Medicine and Medical Research
MICROVESSEL DENSITY
MRI(MAGNETIC RESONANCE IMAGING)
PREDICTIONS
PULSES
TUMOR ANGIOGENESIS
VALIDATION
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Summary:The purpose of this research is to develop a non-invasive predictor of malignancy in breast tumors through the design and preliminary validation of a new form of magnetic resonance imaging (MRI) . The hypothesis is that the spatial distribution of microvasculature around a solid breast lesion is specific for malignancy and can be reliably measured at high resolution by a completely non-invasive, non-contrast-enhanced MRI method. This is being tested by achieving the following: 1. Design/building/testing of ultra-high-strength gradient coils for human breast imaging at 1.5 Tesla (T) and 4T. 2. Design/implementation/testing of MR pulse sequences for selective mapping of microvascular parameters. 3. Correlation of MR-derived microvascular parameters with true microvessel density in a rat model of human breast cancer.