Robust Adaptive Control of Hypnosis During Anesthesia

A closed-loop controller for hypnosis was designed and validated on humans at our laboratory. The controller aims at regulating the Bispectral Index (BIS) - a surrogate measure of hypnosis derived from the electroencephalogram of the patient - with the volatile anesthetic isoflurane administered wit...

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Bibliographic Details
Main Authors: Grieder, Pascal, Gentilini, Andrea, Morari, Manfred, Schnider, Thomas W
Format: Report
Language:English
Subjects:
ADAPTIVE CONTROL SYSTEMS
ANESTHESIA
ANESTHETICS
BIS(BISPECTRAL INDEX)
CLOSED LOOP SYSTEMS
DIAGNOSTIC EQUIPMENT
ELECTROENCEPHALOGRAPHY
FOREIGN REPORTS
HYPNOSIS
IMC(INTERNAL MODEL CONTROLLER)
IONS
ISOFLURANE
MEDICAL RESEARCH
Medicine and Medical Research
Psychology
SWITZERLAND
SYMPOSIA
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Summary:A closed-loop controller for hypnosis was designed and validated on humans at our laboratory. The controller aims at regulating the Bispectral Index (BIS) - a surrogate measure of hypnosis derived from the electroencephalogram of the patient - with the volatile anesthetic isoflurane administered with a closed-circuit breathing system. The control algorithm consists of a cascaded Internal Model Controller (IMC) where the master loop aims at regulating BIS. The slave loop tracks endtidal concentration references provided by the master controller. In this paper, a new tuning method is presented. Papers from 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, October 25-28, 2001, held in Istanbul, Turkey. See also ADM001351 for entire conference on cd-rom.