An LOH Study of Chromosome 8 in Multiplex Prostate Cancer Sibships

This study was designed to identify one or more prostate cancer (CaP) tumor suppressor genes (TSG) on chromosome 8 by assessing the distribution of loss of Heterozygosity (LOH) in brothers from multiplex sibships A strong linkage signal as been demonstrated in these families. LOH was assessed in 202...

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Bibliographic Details
Main Author: Suarez, Brian K
Format: Report
Language:English
Subjects:
CHROMOSOME 8
CHROMOSOMES
GENES
Genetic Engineering and Molecular Biology
GENETICS
LOSS OF HETEROZYGOSITY
Medicine and Medical Research
MULTIPLEXING
PROSTATE CANCER
PROSTATE GLAND
SUPPRESSORS
TISSUES(BIOLOGY)
TSG(TUMOR SUPPRESSOR GENES)
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Summary:This study was designed to identify one or more prostate cancer (CaP) tumor suppressor genes (TSG) on chromosome 8 by assessing the distribution of loss of Heterozygosity (LOH) in brothers from multiplex sibships A strong linkage signal as been demonstrated in these families. LOH was assessed in 202 men with histologically confirmed prostate cancer.