The Discovery of New Antimicrotubule Agents from Hawaiian, Polynesian, and Asian Ethnobotanical Sources

An extract library of 79O extracts of higher plants has been prepared. Plants were selected for extraction based on ethnobotanical information indicating use in cancer therapy in the traditional medical systems of societies of the Pacific Rim. Extracts were tested for cytotoxicity in drug-sensitive...

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Bibliographic Details
Main Author: Hemscheidt, Thomas K
Format: Report
Language:English
Subjects:
ANTIMICROTUBULE AGENTS
BIOASSAY
Biochemistry
BIOLOGICAL EXTRACTS
Biology
BREAST CANCER
CELLS(BIOLOGY)
CHEMOTHERAPY
CYTOTOXICITY
CYTOTOXINS
ETHNOBOTANY
Medicine and Medical Research
METASTASIS
MICROSTRUCTURE
PACIFIC OCEAN ISLANDS
PLANTS(BOTANY)
TUBULAR STRUCTURES
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Summary:An extract library of 79O extracts of higher plants has been prepared. Plants were selected for extraction based on ethnobotanical information indicating use in cancer therapy in the traditional medical systems of societies of the Pacific Rim. Extracts were tested for cytotoxicity in drug-sensitive and drug-resistant breast cancer cell lines and in mechanism-based as says for activity against the cytoskeleton, specifically microtubules and microfilaments. Selected extracts that showed activity in any of the assays were investigated by bioassay-guided fractionation to isolate the active principles and to establish their chemical structures.