The Role of Steroid Receptor Coactivators in the Development of Prostate Cancer

• Main Author: Cho, Jang H
• Format: Report
• Language: English
• Subjects: Anatomy and Physiology; ANDROGENS; CELLS(BIOLOGY); CLONES; FAMILY MEMBERS; GENES; HUMANS; Medicine and Medical Research; NEOPLASMS; NUCLEAR MEDICINE; PROSTATE CANCER; PROSTATE GLAND; PROTEINS; RECEPTOR SITES(PHYSIOLOGY); SENSE ORGANS; STABILITY; STEROIDS; STIMULI; TARGETS; TRANSCRIPTION(GENETICS)

In prostate cancer, androgen receptor (AR) supervises several key genes expressions. In the cell. AR exerts its regulatory control on a target cell only in the presence of its ligand, androgen. The regulatory functions of AR are more complex and are fine-tuned by accessory proteins. These proteins are required for the maximum biological impact by androgen. These modulators, called coactivators, provide a positive stimulus for receptor action. Our laboratory has cloned the first nuclear receptor coactivator SRC-1. SRC-1 and its related family members, SRC-2 and -3, have the capacity to activate the transcriptional activity of steroid receptor. However, the role of steroid receptor coactivators in prostate cancer is still unclear. To understand the function of these genes in the human prostate cancer, we have performed in situ hybridization on human prostate cancer, and generated SRC-3 overexpressing stable cell lines. During two years of this award, we have examined the SRC-3 is highly expressed in the prostate tumors and its expression is highly correlated with tumorigenesis by regulating the cell proliferation and cell growth. The original document contains color images. All DTIC reproductions will be in black and white.