90-Day Oral Gavage Toxicity Study of C9-C16 Aromatic Fraction Jet-A in Female Sprague-Dawley CD Rats and Male C57BL/6 Mice

This study was conducted to characterize the potential toxic effects of C9-C16 aromatic fraction of Jet-a in female Sprague-Dawley CD rats and male C57BL/6 mice following daily oral administration for 90 days. Four groups of 15 female/rats group and 15 male mice/group were administered a daily oral...

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Bibliographic Details
Main Authors: Smith, P B, Veley, K E, Yarrington, J T, Slauter, R W, Vorhees, D
Format: Report
Language:English
Subjects:
90-DAY ORAL STUDY
AROMATIC FRACTION
BLOOD CHEMISTRY
BLOOD COUNTS
C57BL/6 MICE
Chemical, Biological and Radiological Warfare
CLINICAL MEDICINE
DOSAGE
FUELS
HEMATOCRIT
HEMOGLOBIN
JET FUEL
Medicine and Medical Research
ORAL DOSAGE
PE65502F
RESPONSE(BIOLOGY)
SPRAGUE-DAWLEY RATS
TOXICITY
Toxicology
WUAFRLSTTROT71
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Summary:This study was conducted to characterize the potential toxic effects of C9-C16 aromatic fraction of Jet-a in female Sprague-Dawley CD rats and male C57BL/6 mice following daily oral administration for 90 days. Four groups of 15 female/rats group and 15 male mice/group were administered a daily oral gavage dose of the test substance at 0 (vehicle control), 20, 100, and 500 mg/kg in a corn oil vehicle. Mean hemoglobin, hematocrit, and red blood cell counts were decreased in the mid- and high-dose female rats. Necropsy examinations revealed enlarged livers in the high-dose rats. This correlated with the organ weight measurements indicating significant liver weight increases (absolute and relative to brain and body weight) in the high-dose rats compared with their controls. There were no pathological lesions observed or changes in - serum chemistry parameters which were related to the test substance. Clinical observations included hunched posture in all groups of mice, with the frequency of the observation increasing with higher doses. Lethargy was recorded from all of the high-dose mice and half of the high-dose rats. Lethargy was also observed in 5/15 low-dose and 12/15 mid-dose mice. Salivation was observed in all of the high-dose rats and from 6/15 from the mid-dose rats. Rats in the mid- and high-dose groups were observed shoveling their contact bedding with their noses within minutes after being dosed. The shoveling and salivation observed in the rats is consistent with an irritation response in the mouth. There were no apparent effects of the test substance on the body weights during the study. Increased food consumption was observed in the rats that received test substance, with significant increases observed during most of the study in the high-dose group.