Tolerance to the Ocular and Cardiovascular Effects of Repeated Low-Level Exposure to Sarin Vapor

Inhibition of acetylcholinesterase (AChE) by the nerve agent sarin (GB) results in accumulation of acetylcholine and excessive cholinergic stimulation. Little data exists in the literature regarding the effects of low-level repeated exposure to GB vapor. In the present study male rats were exposed t...

Full description

Saved in:
Bibliographic Details
Main Authors: Dabisch, P A, To, S D, Kerut, E K, Miller, D B, Burnett, D C, Jakubowski, E M, Muse, W T, Davis, E A, Benton, B J, Hulet, S W
Format: Report
Language:English
Subjects:
ACETYLCHOLINE
ACETYLCHOLINESTERASE
Anatomy and Physiology
AUTONOMIC NERVOUS SYSTEM
Biochemistry
CARDIOVASCULAR SYSTEM
Chemical, Biological and Radiological Warfare
CHOLINERGIC NERVES
COMPONENT REPORTS
EXPOSURE(PHYSIOLOGY)
EYE
GB AGENT
INHIBITION
LOW LEVEL
NERVE AGENTS
RATS
SARIN VAPOR
SYMPOSIA
TOLERANCE
VAPORS
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Inhibition of acetylcholinesterase (AChE) by the nerve agent sarin (GB) results in accumulation of acetylcholine and excessive cholinergic stimulation. Little data exists in the literature regarding the effects of low-level repeated exposure to GB vapor. In the present study male rats were exposed to multiple low-level inhalation exposures to GB vapor. The data from the present study demonstrate that multiple inhalation exposures to GB vapor result in tolerance to the ocular and autonomic effects of GB vapor. While the observed decrease in the potency of GB in rats cannot he attributed to a reduction in the inhibitory effect of GB additional experiments are needed to determine the exact mechanism of the tolerance observed. See also ADM001736, Proceedings for the Army Science Conference (24th) held on 29 November - 2 December 2004 in Orlando, Florida.