Characterization of Breast Masses Using a New Method of Ultrasound Contract Agent Imaging in a 3D Mapping of Vascular Anomalies

Doppler ultrasound and other imaging modalities have been used to assess characteristics of vasculature associated with malignant breast masses. 3D contrast refill imaging should help visualize slow-flow in small neo-vasculature associated with these masses. The dual-transducer method proposed shoul...

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Bibliographic Details
Main Author: LeCarpentier, Gerald L
Format: Report
Language:English
Subjects:
Acoustic Detection and Detectors
ACQUISITION
Anatomy and Physiology
ANOMALIES
BLOOD VESSELS
BREAST CANCER
CARDIOVASCULAR SYSTEM
CLINICAL MEDICINE
COMPUTATIONS
CONFIGURATIONS
DISPLAY SYSTEMS
DOPPLER SYSTEMS
IMAGE PROCESSING
MAMMARY GLANDS
MAPPING
Medicine and Medical Research
NEOPLASMS
PARAMETRIC ANALYSIS
PATIENTS
ULTRASONICS
VASCULAR DISEASES
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Summary:Doppler ultrasound and other imaging modalities have been used to assess characteristics of vasculature associated with malignant breast masses. 3D contrast refill imaging should help visualize slow-flow in small neo-vasculature associated with these masses. The dual-transducer method proposed should provide vascular mapping while minimizing acquisition time, the major limitation of techniques such as interval-imaging (I-I) and real-time (RT) imaging. Phantom tube-flow studies from Y2 were further quantified. A phantom kidney model initially tested in Y2 has been extensively studied and compared to I-I and RT methods. Image volumes reconstructed using the dual-transducer method displayed remarkable spatial detail. After accounting for contrast decay, mean transit times (MTTs) for image planes derived from reconstructed image volumes were consistent (p0.05) with corresponding single I-I and RT scans. In addition, the development of a parametric image display scheme has been undertaken. Raw images highlighting differences in MTT throughout the model have been generated, and refinements to parametric calculations are currently underway. Limitations of the clinical ultrasound machine were still problematic during Y3, and no patient data has been acquired. We hope to conduct a slightly abridged clinical phase during a no-cost extension period. Y3 results are presented here.