Generation Sampling and Analysis for Low-Level GB (SARIN) Vapor for Inhalation Toxicology Studies

This study tested and optimized various methodologies to generate, sample, and characterize sarin (GB) test atmospheres in an inhalation chamber, particularly at low-vapor levels. A syringe drive/spray atomization system produced GB vapor at lethal concentrations of 1-44 mg/m3. A saturator cell was...

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Bibliographic Details
Main Authors: Muse, Jr , William T, Thomson, Sandra A, Matson, Kathy L, Crouse, Charles L
Format: Report
Language:English
Subjects:
Anatomy and Physiology
ATOMIZATION
CHEMICAL WARFARE AGENTS
Chemical, Biological and Radiological Warfare
CONCENTRATION(CHEMISTRY)
GB AGENT
INHALATION
METHODOLOGY
SATURATION
SUBLETHAL DOSAGE
TOXICITY
Toxicology
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Summary:This study tested and optimized various methodologies to generate, sample, and characterize sarin (GB) test atmospheres in an inhalation chamber, particularly at low-vapor levels. A syringe drive/spray atomization system produced GB vapor at lethal concentrations of 1-44 mg/m3. A saturator cell was used to generate GB vapor at sub-lethal concentrations from 1 mg/m down to very low GB levels approaching the TLV-TWA of 0.0001 mg/m3. Both generation techniques demonstrated the ability to produce stable vapor concentrations over extended exposure periods. This capability was important to determine sub-lethal nerve agent effects for inhalation toxicology studies. In addition, the techniques employed for producing and maintaining low-level GB vapor would lay the foundation for testing other chemical warfare agents, such as GF or VX. Prepared in collaboration with Geo-Centers Inc, Aberdeen Proving Grounds, MD.