Generation, Sampling, and Analysis for Low-Level GF (Cyclo-Sarin) Vapor for Inhalation Toxicology Studies

The generation, sampling, and analysis system used for low-level GB inhalation studies was modified to test the nerve agent GF. A saturator cell used in conjunction with an inhalation chamber generated low level OF vapor at concentrations ranging from 0.004 - 0.05 mg/cu m. Additional testing with a...

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Bibliographic Details
Main Authors: Muse, Jr , William T, Thomson, Sandra A, Crouse, Charles L, Matson, Kathy L
Format: Report
Language:English
Subjects:
AGENT GENERATION
Anatomy and Physiology
ATOMIZATION
CHEMICAL AGENTS
Chemical, Biological and Radiological Warfare
CONCENTRATION(COMPOSITION)
CYCLOHEXYL METHYLPHOSPHONOFLUORIDATE
GB AGENT
GF(CYCLO-SARIN)
INHALATION
INHALATION TOXICOLOGY
LOW LEVEL
MEIOSIS
NERVE AGENTS
SAMPLING
SARIN
SATURATION
SATURATOR CELLS
SPRAY ATOMIZATION
SUBLETHAL DOSAGE
Toxicology
VAPORS
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Summary:The generation, sampling, and analysis system used for low-level GB inhalation studies was modified to test the nerve agent GF. A saturator cell used in conjunction with an inhalation chamber generated low level OF vapor at concentrations ranging from 0.004 - 0.05 mg/cu m. Additional testing with a syringe drive spray atomization system generated OF vapor concentrations from 0.7 - 2 mg/cu m. This capability was important to determine sub-lethal effects (primarily meioses) for inhalation toxicology studies. In addition, the techniques successfully employed for this study would lay the foundation for testing low-level VX. Prepared in collaboration with GEO-CENTERS, Inc., part of Science Applications International Corp.