Seroincidence and Phylogeny of Human Immunodeficiency Virus Infections in a Cohort of Commercial Sex Workers in Montevideo, Uruguay

A cohort study involving 60 human immunodeficiency virus (HIV) negative male transvestite commercial sex workers (CSWs) was conducted in Montevideo, Uruguay in 1999 2001. Serum samples were tested for HIV by an enzyme-linked immunosorbent assay screening with immunoblot confirmation. Six participant...

Full description

Saved in:
Bibliographic Details
Main Authors: Vinoles, Jose, Serra, Margarita, Russ, Jose C, Ruchansky, Dora, Sosa-Estani, Sergio, Montano, Silvia M, Carrion, Gladys, Eyzaguirre, Lindsay M, Carr, Jean K, Olson, James G
Format: Report
Language:English
Subjects:
BLOOD SERUM
CANNABIS
COMMERCE
CSW(COMMERCIAL SEX WORKERS)
ENZYME-LINKED IMMUNOSORBENT ASSAY
ENZYMES
FOREIGN REPORTS
GENOME
HAZARDS
HIGH RATE
HUMAN IMMUNODEFICIENCY VIRUSES
IDU(INJECTING DRUG USE)
IMMUNOASSAY
INFECTIOUS DISEASES
MALES
Medicine and Medical Research
Microbiology
ORAL INTAKE
REPRINTS
RETROVIRUSES
RISK
SAMPLING
SEROLOGY
SEX
SEXUAL ENCOUNTERS
STI(SEXUALLY TRANSMITTED INFECTIONS)
URUGUAY
VIRUS DISEASES
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A cohort study involving 60 human immunodeficiency virus (HIV) negative male transvestite commercial sex workers (CSWs) was conducted in Montevideo, Uruguay in 1999 2001. Serum samples were tested for HIV by an enzyme-linked immunosorbent assay screening with immunoblot confirmation. Six participants seroconverted for an incidence-density rate of 6.03 (95% confidence interval 2.21 13.12) per 100 person-years. Inconsistent condom use during client sex (adjusted hazard ratio [AHR] 6.7), during oral sex (AHR 5.6), and at the last sexual encounter (AHR 7.8), and use of marihuana (AHR 5.4) were marginally associated with HIV seroconversion. Five samples were genotyped in the protease and reverse transcriptase regions; three were subtypes B and two were BF recombinants. Full genome analysis of four samples confirmed all three subtype B samples and one of the two BF recombinants. Male transvestite CSWs sustained a high rate of HIV infection. Larger prospective studies are required to better define subtypes and associated sexual and drug-related risk factors. Pub. in Am. Journal Tropical Medicine Hygiene, v72 n4, p.495-500, 2005.