Interaction Between Dietary Factors and Inflammation in Prostate Carcinogenesis

We are investigating whether inflammation can enhance prostate carcinogenesis in a rat model of dietary charred meat carcinogen induced cancers, and, whether antioxidant and other chemopreventative compounds can reduce prostate cancer in this model. In this period we have extended our rat studies to...

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Bibliographic Details
Main Author: De Marzo, Angelo M
Format: Report
Language:English
Subjects:
ANTIOXIDANTS
Biochemistry
C-MYC PROTEIN
CARCINOGENESIS
CARCINOGENS
CHARRED MEAT
CHEMOPREVENTION
DIET
Genetic Engineering and Molecular Biology
INFLAMMATION
Medicine and Medical Research
MOUSE MODELS
ONCOGENESIS
PHIP
PHIP INDUCED PROSTATE CANCER
PREVENTION
PROSTATE CANCER
RAT MODELS
RATS
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Summary:We are investigating whether inflammation can enhance prostate carcinogenesis in a rat model of dietary charred meat carcinogen induced cancers, and, whether antioxidant and other chemopreventative compounds can reduce prostate cancer in this model. In this period we have extended our rat studies to show that PhIP will cause prostatic intraepithelial neoplasia in the mouse, providing a greatly enhanced ability to study molecular mechanisms of PhIP induced prostate carcinogenesis and for prevention of prostate cancer induced by PhIP. We have also began to extensively characterize another mouse model of prostate cancer that we will also be able to used in studies of PhIP induced prostate cancer and prevention. Finally, we have begun to extend our studies to understanding the molecular mechanisms of PhIP induced prostate cancer by developing an assay to detect CpG dinucleotide hypermethyalation in the rat GSTP1 promoter. These studies set the stage for us to complete all of our stated aims in year 3 of this proposal. The original document contains color images.