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Effectiveness of Halogen-Based Disinfectants Against Acinetobacter Baumannii: Wound Care and Environmental Decontamination
Historically, Acinetobacter baumannii has not been considered an important human pathogen. However, a surprisingly high number of multidrugresistant A. baumannii war wound, bloodstream and osteomyelitis infections are occurring in American soldiers injured in Iraq/Kuwait (Operation Iraqi Freedom) an...
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Main Authors: | , , , |
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Format: | Report |
Language: | English |
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Summary: | Historically, Acinetobacter baumannii has not been considered an important human pathogen. However, a surprisingly high number of multidrugresistant A. baumannii war wound, bloodstream and osteomyelitis infections are occurring in American soldiers injured in Iraq/Kuwait (Operation Iraqi Freedom) and in Afghanistan (Operation Enduring Freedom). Thermal projectiles, (e.g., shrapnel, projectile injuries, or traumatic blast) carry the bacterium directly into combat wounds. Because of its resistance to multiple antibiotics, A. baumannii is emerging as an important pathogen among combat casualty victims and has become a significant clinical disease. With the number of A. baumannii infections rapidly rising, added to A. baumannii's well-established resistance to multiple antibiotics, underscores the relevance for identifying the most excellent disinfectants for reducing A. baumannii populations in combat wounds and combat health care settings. We compared the bacteriostatic and bactericidal activities of five commercially available U.S. halogenbased disinfectants against A. baumannii, along with a standard E. coli comparator, in a novel bacterial culture system that incorporated a three log range of organic growth media concentrations. We report the highest dilutions of stock disinfectant able to inhibit replication or kill the bacteria, denoted as the maximum inhibitory dilution (MID) and maximum bactericidal dilution (MBD), respectively.
See also ADM002075., The original document contains color images. |
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