Generation, Sampling and Analysis for Low-Level GB (Sarin) Vapor for Inhalation Studies

This study tested and optimized various methodologies to generate, sample and characterize GB test atmospheres in an inhalation chamber, particularly at low vapor levels. A syringe drive/spray atomization system produced GB vapor at lethal concentrations of 1- 44 mg/m3. A saturator cell was used to...

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Bibliographic Details
Main Authors: Muse, Jr , William T, Thomson, Sandra A, Matson, Kathy L, Crouse, Charles L
Format: Report
Language:English
Subjects:
CHAMBERS
CHEMICAL WARFARE AGENTS
Chemical, Biological and Radiological Warfare
CONCENTRATION(COMPOSITION)
EXPOSURE(GENERAL)
GB AGENT
INHALATION
LETHALITY
Toxicology
VAPORS
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Description
Summary:This study tested and optimized various methodologies to generate, sample and characterize GB test atmospheres in an inhalation chamber, particularly at low vapor levels. A syringe drive/spray atomization system produced GB vapor at lethal concentrations of 1- 44 mg/m3. A saturator cell was used to generate GB vapor at sub-lethal concentrations down to levels approaching the TLV-TWA of 0.0001 mg/m3. Both generation techniques demonstrated the ability to produce stable vapor concentrations over extended exposure periods for inhalation toxicology studies. The techniques employed for this study would lay the foundation for testing other chemical warfare agents, such as GF or VX. See also ADM001523.