Extremely High Peak Power Pulsed RF and UWB EMR Effects on Genomic Transcription - Microarray Assessment

In this study, the pulsed UWB TEMF exposures were to a very high average peak electric field amplitude (102.17 + 5.10 kV/m), a very rapid rise time (229.46 + 25.56 ps), a very small pulse width (0.80 + 0.02 ns), and a reasonable experimental exposure duration (a total of 90 minutes pulsed UWB TEMF e...

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Bibliographic Details
Main Authors: Meltz, Martin L, Nayak, Bijaya, Galindo, Cynthia
Format: Report
Language:English
Subjects:
ACTIVATION
ARRAYS
CELLS(BIOLOGY)
ELECTROMAGNETIC FIELDS
EXPOSURE(GENERAL)
EXTREMELY HIGH FREQUENCY
Genetic Engineering and Molecular Biology
GENOME
MICROARRAY ASSESSMENT
PEAK POWER
PULSED UWB
RADIOFREQUENCY PULSES
Radiofrequency Wave Propagation
TRANSCRIPTION(GENETICS)
UWB(ULTRAWIDEBAND)
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Summary:In this study, the pulsed UWB TEMF exposures were to a very high average peak electric field amplitude (102.17 + 5.10 kV/m), a very rapid rise time (229.46 + 25.56 ps), a very small pulse width (0.80 + 0.02 ns), and a reasonable experimental exposure duration (a total of 90 minutes pulsed UWB TEMF exposure). This study demonstrates for the first time that pulsed UWB electromagnetic field exposure does not induce p53 mRNA expression, does not effect p53 protein accumulation, has no effect on the transactivation of its target genes, and there is no cell growth arrest or apoptosis. Lack of p53 protein accumulation and absence of transcriptional activation of p53 target genes in response to pulsed UWB electromagnetic field exposure suggest that UWB TEMF exposure does not induce DNA damage, and that this type of radiation might not be a stress factor to the cells.