Interaction Between Dietary Factors and Inflammation in Prostate Carcinogenesis

We discovered that PhIP treatment causes widespread epithelial atrophy in the rat ventral prostate that precedes the development of PIN. This data supports the contention that the PhIP-treated rat model of prostate cancer is a valid model for studying the development of PIA, PIN and early carcinoma....

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Bibliographic Details
Main Author: De Marzo, Angelo M
Format: Report
Language:English
Subjects:
ATROPHY
CHEMOPREVENTION
DIET
EPITHELIUM
Food, Food Service and Nutrition
INFLAMMATION
MEDICAL RESEARCH
Medicine and Medical Research
MUTATIONS
ONCOGENESIS
PHIP
PIA(PROLIFERATIVE INFLAMMATORY ATROPHY)
PROSTATE CANCER
PROSTATE GLAND
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Summary:We discovered that PhIP treatment causes widespread epithelial atrophy in the rat ventral prostate that precedes the development of PIN. This data supports the contention that the PhIP-treated rat model of prostate cancer is a valid model for studying the development of PIA, PIN and early carcinoma. The results raise the novel hypothesis that suggests that the extensive atrophy that is seen in men with prostate cancer, and which has been associated with PIN and prostate cancer, may be caused by ingestion of cooked meats. This result will open up new areas of investigation into this question. For example, it would be highly feasible and reasonable to ask in a pathological-epidemiological study to determine whether the extent of prostate atrophy correlated with dietary intake of PhIP. Also, broccoli and celebrex can decrease mutations in the rat prostate induced by PhIP indicating they may be effective chemopreventative agents. Preliminary analyzes indicates that short term treatment with PhIP (4 weeks) combined with viral infection does not increase PIN or prostate cancer lesions in Fisher Rats suggesting that longer term treatment is necessary. Additional studies to complete this work are ongoing using funding sources outside of the DOD. In addition we have successfully contributed to the further instruction of an outstanding Urologist-In-Training in many aspects of prostate cancer research. The original document contains color images.